Immunomodulatory Properties of Polysaccharides from Lentinula edodes
Aleksander Roszczyk, Jadwiga Turło, Radosław Zagożdżon, Beata Kaleta
Abstract
Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects. L. edodes-derived polysaccharides are the most valuable compounds, with anticancer, antioxidant, antimicrobial, and immunomodulatory properties. It has been demonstrated that their biological activity depends on the extraction method, which affects monosaccharide composition, molecular weight, branching degrees, and helical conformation. In this review, we discuss the immunomodulatory properties of various polysaccharides from L. edodes in animal models and in humans.
Topics & Concepts
LentinulaPolysaccharideMushroomAntimicrobialMonosaccharideChemistryAntioxidantMedicinal fungiEdible mushroomFood scienceBiochemistryBiologyOrganic chemistryPolysaccharides and Plant Cell WallsFungal Biology and ApplicationsSeaweed-derived Bioactive Compounds