Modular allylation of C(sp <sup>3</sup> )–H bonds by combining decatungstate photocatalysis and HWE olefination in flow
Luca Capaldo, Stefano Bonciolini, Antonio Pulcinella, Manuel Nuño, Timothy Noël
Abstract
)-H bonds. Our sequence features the merger of two distinct steps to accomplish this goal, including a photocatalytic Hydrogen Atom Transfer and an ensuing Horner-Wadsworth-Emmons (HWE) reaction. This practical protocol enables the modular and scalable allylation of valuable building blocks and has been applied to structurally complex molecules.
Topics & Concepts
PhotocatalysisModular designChemistryFlow (mathematics)PhotochemistryOrganic chemistryPhysicsComputer scienceCatalysisMechanicsOperating systemChemical Synthesis and ReactionsRadical Photochemical ReactionsInnovative Microfluidic and Catalytic Techniques Innovation