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G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation

Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Alicia L Thurber, Minqi Zhou, Zeina Msheik, Yonatan Perez, Lea T. Grinberg, Salvatore Spina, Richard M. Ransohoff, Arnold R. Kriegstein, William W. Seeley, Tomasz J. Nowakowski, Xianhua Piao

2025Neuron11 citationsDOI

Topics & Concepts

MicrogliaBiologyPhagocytosisNeuroscienceCell biologyAlzheimer's diseaseDownregulation and upregulationReceptorImmunologyDiseaseGeneInflammationMedicineGeneticsPathologyNeuroinflammation and Neurodegeneration MechanismsNeuropeptides and Animal PhysiologyNeurogenesis and neuroplasticity mechanisms
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation | Litcius