Glucose Oxidase-Modified Metal–Organic Framework for Starving-Enhanced Chemodynamic Therapy
Yingyan Liu, Kaixiu Chen, Yapu Yang, Pengfei Shi
Abstract
Chemodynamic therapy (CDT) has been considered an emerging strategy for cancer treatment. However, the tumor microenvironment (TME) with slight acidity and restricted H 2 O 2 limits the efficacy of CDT. Here, we report a Hf-Mn-TCPP (Hf = hafnium; Mn-TCPP = 5, 10, 15, 20-tetrakis (4-carboxyphenyl) porphyrinato-manganese (II) chloride) loaded with glucose oxidase (GOx) to realize starving-enhanced CDT. GOx consumes glucose to produce H 2 O 2 and gluconic acid. Gluconic acid increases the acidity of TME and subsequently provides favorable conditions for the Fenton-like reaction based on Hf-Mn-TCPP. The results indicate that GOx-modified Hf-Mn-TCPP provided a great therapeutic effect in starvation-enhanced CDT in vitro and in vivo.