Single-cell RNA profiling of blood CD4+ T cells identifies distinct helper and dysfunctional regulatory clusters in children with SLE
Preetha Balasubramanian, Uthra Balaji, Marina Silva Santos, Jeanine Baisch, Cynthia Smitherman, Lynnette Walters, Paola Sparagana, Lorien Nassi, Katie Stewart, Julie A. Fuller, Terry K. Means, Virginia Savova, Jacques Banchereau, Tracey Wright, Virginia Pascual, Jinghua Gu, Simone Caielli
Topics & Concepts
Cytotoxic T cellImmunologyBiologyImmune systemLupus nephritisInterleukin 21T cellSystemic lupus erythematosusEffectorDownregulation and upregulationAntibodyDiseaseLupus erythematosusT helper cellMemory T cellCD8RNAInnate immune systemAutoimmune diseaseAutoimmunityDysfunctional familyInflammationPeripheral bloodB cellSingle-cell and spatial transcriptomicsT-cell and B-cell ImmunologyImmune Cell Function and Interaction