Drugging the Next Undruggable KRAS Allele-Gly12Asp
Qinheng Zheng, D. Matthew Peacock, Kevan M. Shokat
Abstract
Since its discovery as the first human oncogene in 1983, the small GTPase KRAS has been a major target of cancer drug discovery. The paper reported in this issue describes a long-awaited small molecule drug candidate of the oncogenic KRAS (G12D) mutant for the treatment of currently incurable pancreatic cancer.
Topics & Concepts
KRASDrug discoveryChemistryOncogeneCancerSmall moleculeComputational biologyCancer researchSmall GTPaseAnticancer drugDrugPharmacologyMutationGeneticsGeneBiologyBiochemistrySignal transductionCell cycleProtein Kinase Regulation and GTPase SignalingDrug Transport and Resistance MechanismsReceptor Mechanisms and Signaling