Incidence, prevalence and clinical presentation of inflammatory bowel diseases in Northern France: a 30-year population-based study
Hélène Sarter, Thibaut Crétin, Guillaume Savoye, Mathurin Fumery, Ariane Leroyer, Luc Dauchet, Thierry Paupard, Hugues Coevoet, Pauline Wils, Nicolas Richard, Dominique Turck, Delphine Ley, Corinne Gower‐Rousseau, Eric Agoute, Najib Al Ghossaini, Raied Al Hameedi, Maria Khatib, SA Turk, Jean‐Marie André, Matthieu Antoine, Michel Antonietti, A Aouakli, Laura Armengol‐Debeir, I Aroichane, Fadi Assi, É. Auxenfants, Alina Avram, Kassem Azzouzi, D Bankovski, B Barbry, Nicolas Bardoux, Philippe Baron, A Baudet, Pauline Bayart, B Bazin, A Bebahani, J P Becqwort, Houssem Ben Ali, E Ben Soussan, Coralie Bénard, V Benet, Corinne Benguigui, Abdeslam Bental, Sara Bentaleb-Bellati, I. Berkelmans, J. Bernet, K Bernou, Nathalie Bertiaux-Vandaële, P Bertot, Valérie Bertrand, Emilie Biloud, Nathalie Biron, Benjamin Bismuth, Cyril Blanchard, M Bleuez, F Blondel, Valérie Blondin, Mariusz Bobula, Philippe Bohont, Eléonore Boivin, V. B. Djemah, E Boniface, P Bonnière, P Bonvarlet, Arnaud Boruchowicz, R Bostvironnois, Médina Boualit, Ahlem Bouazza, B. Bouché, Christian Boudailler, C Bourgeaux, Morgane Bourgeois-Fumery, Arnaud Bourguet, A Bourienne, Hamza Boutaleb, Alexis Bouthors, Julien Branche, Franck Brazier, Marie Bridenne, Hélène Brihier, Laura Bril, P. Bulois, P Burgiere, J Butel, Jean–Yves Canva, V. Canva-Delcambre, Florence Cardot, Sandrine Carette, P. Carpentier, M Cassagnou, J F Cassar, F. Castex, Pascale Catala, Stéphane Cattan, Sylviane Catteau, B Caujolle, G Cayron, C Chandelier, Cloé Charpentier, M Chavance-Thelu
Abstract
Background: In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period. Methods: Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time. Findings: (APC: +1.3%, p < 0.0001). The largest increase was observed in children (+4.3% in CD, p < 0.0001; +5.4% in UC, p < 0.0001) followed by young adults aged 17-39 years (+1.9% in CD, p < 0.0001; +1.5% in UC, p < 0.0001). The increase in UC incidence was significantly higher in women than in men (+1.9% in women, +0.8% in men; p = 0.006). We estimated that in our area, by 2030, nearly 0.6% of the population will have IBD. Interpretation: The persistent increase of IBD incidence among children and young adults but also in women with UC in Northern France, suggests the persistence of substantial predisposing environmental factors. Funding: Santé Publique France; INSERM; Amiens, Lille and Rouen University Hospitals.