E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma
YanLan Li, Lingbo Bao, Hong Zheng, Mingying Geng, TianYi Chen, Xiaoyan Dai, Xiao He, Lujie Yang, Chengyi Mao, Yuan Qiu, Xu Yu, Dong Wang, Meng Xia Li, Qian Chen
Abstract
This work suggests that TRIM21/TIF1γ/β-catenin axis is involved in the progression of human GBM. TRIM21 is a promising therapeutic and prognostic biomarker for glioma with hyperactive β-catenin.
Topics & Concepts
Ubiquitin ligaseUbiquitinCell biologyCancer researchChemistryGliomaGene knockdownBiologyCell cultureGeneticsBiochemistryGeneinterferon and immune responsesUbiquitin and proteasome pathwaysCancer Mechanisms and Therapy