A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy
Mingjie Xia, Zhihui Guo, Xinming Liu, Yang Wang, Chunsheng Xiao
Abstract
Glutathione-responsive sulfur dioxide polymer prodrug could consume glutathione and release SO 2 to cooperatively elevate the intracellular ROS level, leading to selective induction of ferroptosis in gastric cancer cells.
Topics & Concepts
GlutathioneProdrugChemistryLipid peroxidationCancer cellCancerCancer researchGPX4In vivoProgrammed cell deathPharmacologyBiochemistryApoptosisOxidative stressBiologyMedicineInternal medicineEnzymeBiotechnologyGlutathione peroxidaseFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer