Interleukin-23 engineering improves CAR T cell function in solid tumors
Xingcong Ma, Peishun Shou, Christof C. Smith, Yu‐Hui Chen, Hongwei Du, Chuang Sun, Nancy P. Kren, Daniel Michaud, Sarah Ahn, Benjamin G. Vincent, Barbara Savoldo, Yuliya Pylayeva‐Gupta, Shuqun Zhang, Gianpietro Dotti, Yang Xu
Topics & Concepts
Interleukin 21Chimeric antigen receptorCytotoxic T cellInterleukin 12Interleukin 3IL-2 receptorT cellGranzyme BAntigen-presenting cellZAP70CytokineNatural killer T cellAutocrine signallingCell biologyBiologyMolecular biologyCancer researchChemistryReceptorImmunologyImmune systemIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology