Silanol: a bifunctional group for peptide synthesis and late-stage functionalization
Qi-Long Hu, Ke‐Qiang Hou, Jian Li, Ge Yang, Zhendong Song, Albert S. C. Chan, Xiao‐Feng Xiong
Abstract
Efficient Pd-catalyzed <italic>ortho</italic>-olefination of Tyr residues by employing silanol as a directing group with high chemo- and site-selectivity was developed. Orthogonal protection strategies were also successfully applied to SPPS.
Topics & Concepts
SilanolBifunctionalSurface modificationSelectivityCombinatorial chemistryPeptideGroup (periodic table)ChemistryCatalysisOrganic chemistryBiochemistryPhysical chemistryChemical Synthesis and AnalysisCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods