Neuronal DAF-16-to-intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans
Masaharu Uno, Yuri Tani, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Ryoji Abe, Takuya Kurihara, Eisuke Nishida
Abstract
knockout in neurons and the intestine, respectively. In addition, the systemic regulation of intestinal DAF-16 required the IIS pathway in intestinal and neurons. Collectively, these results highlight the importance of the neuronal DAF-16-to-intestinal DAF-16 communication for organismal lifespan regulation.
Topics & Concepts
Caenorhabditis elegansBiologyCell biologyExtension (predicate logic)Developmental biologyNeuroscienceGeneticsGeneComputer scienceProgramming languageGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatoninBirth, Development, and Health