A dual-type I/II NIR photosensitizer for effective cancer photodynamic therapy with enhanced ROS generation
Shuhua Cao, Yuchang Liu, Xi–Shi Tai, Li Shen, Hekai Yang, Fahui Li, Binglin Sui, Pengju Ma, Lingxuan Zhu, Bin Gao, Anlin Wang, Mohammad Azam
Abstract
), which facilitated more efficient intersystem crossing (ISC) from the singlet to triplet state, thereby promoting greater ROS generation. Experiments showed that C1 and C2 were located in mitochondria and could cause a decrease in mitochondrial membrane potential, leading to cell death. Animal experiments have shown that C2 effectively suppressed tumor growth without side effects.
Topics & Concepts
PhotosensitizerPhotodynamic therapyCancer therapyChemistryCancer researchCancerPhotochemistryMedicineInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials