Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains
Bin Song, Yun Chen, Xin Liu, Fei Yuan, Eddie Yong Jun Tan, Yixuan Lei, Ning Song, Yinqi Han, Bruce D. Pascal, Patrick R. Griffin, Cheng Luo, Bin Wu, Dahai Luo, Jie Zheng
Topics & Concepts
MDA5Cell biologySignal transducing adaptor proteinRIG-IBiologyRNAUbiquitinAllosteric regulationPlasma protein bindingSignal transductionBiochemistryEnzymeRNA interferenceGeneinterferon and immune responsesImmune Response and InflammationNF-κB Signaling Pathways