Theoretical Description for Anti-COVID-19 Drug Remdesivir Electrochemical Determination, Assisted by Squaraine Dye–Ag2O2 Composite
Volodymyr Tkach, Marta V. Kushnir, Sílvio De Oliveira, Yana G. Ivanushko, Alla Velyka, Anzhelika Molodianu, Petró Yagodynets, Жолт Кормош, Lucinda V. Reis, Olga V. Luganska, Каріна Паламарек, Yuliia Bredikhina, S Chauhan, H Harapan, N Itoh, A Yufika, W Winardi, S Keam, H Te, D Megawati, Z Hayati, A Wagner, M Mudatsir, M Tay, C Poh, L Rnia, P Macary, L Ng, R Alsayed, M Kadhom, E Yousif, D Sabir, L Figueroa-Valverde, F Daz-Cedillo, M Lpez-Ramos, M Rosas-Nexticapa, M Mateu-Armad, R Garcimarrero, R Cauich-Carrillo, Y Ortiz-Ake, N Hosny, Y Sherif, R Eastman, J Roth, K Brimacombe, A Simeonov, M Shen, S Patnaik, M Hall, Remdesivir, J Grein, N Ohmagari, D Shin, G Diaz, E Asperges, A Castagna, T Feldt, G Green, M Green, F.-X Lescure, E Nicastri, R Oda, K Yo, E Quiros-Roldan, A Studemeister, J Redinski, S Ahmed, J Bernett, D Chelliah, D Chen, S Chihara, S Cohen, J Cunningham, A D'arminio Monforte, S Ismail, H Kato, G Lapadula, E L'her, T Maeno, S Majumder, M Massari, M Mora-Rillo, Y Mutoh, D Nguyen, E Verweij, A Zoufaly, A Osinusi, A Dezure, Y Zhao, L Zhong, A Chokkalingam, E Elboudwarej, L Telep, L Timbs, I Henne, S Sellers, H Cao, S Tan, L Winterbourne, P Desai
Abstract
For the first time, the remdesivir anti-COVID-19 drug electrochemical determination has been evaluated theoretically. In this work, an anodic process involving the Squaraine Dye – Ag2O2 composite has been evaluated. The mechanism of the electroanalytical process is branched, which implies relatively dynamic behavior. Nevertheless, the correspondent mathematical model analysis, made by linear stability theory and bifurcation analysis, confirms the composite electroanalytical efficiency as an electrode modifier.