Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes
Rafael E. Sanchez-Pupo, Brooke L. O’Donnell, Danielle Johnston, Laszlo Gyenis, David W. Litchfield, Silvia Penuela
Abstract
The channel-forming protein pannexin 2 is transcriptionally regulated in the skin and promotes programmed cell death of keratinocytes after UV radiation. PANX2 is present at all ages in the mouse skin and promotes apoptosis of UV-irradiated keratinocytes regardless of its cleavage by executioner caspases.
Topics & Concepts
BiologyCell biologyApoptosisKeratinocyteEpidermis (zoology)Programmed cell deathIn vitroEndogenyPannexinCell cultureMembrane glycoproteinsMolecular biologyCytotoxicityGlycoproteinCellCaspaseSignal transductionHuman skinProto-Oncogene Proteins c-mycCell growthMembrane proteinConnexins and lens biologySkin Protection and AgingDermatologic Treatments and Research