A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity
Tingting Du, Songwen Lin, Ming Ji, Nina Xue, Yichen Liu, Zhihui Zhang, Kehui Zhang, Jingbo Zhang, Yan Zhang, Qinghua Wang, Sheng Li, Yan Li, Duo Lü, Xiaoguang Chen, Heng Xu
Topics & Concepts
PaclitaxelDU145ColchicineTubulinMicrotubulePharmacologyNocodazoleCancerCancer cellCancer researchBiologyMedicineChemistryCellCell biologyBiochemistryInternal medicineCytoskeletonLNCaPMicrotubule and mitosis dynamicsCancer therapeutics and mechanismsCancer Mechanisms and Therapy