Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors
Hui Shen, Yiran Ge, Junwei Wang, Hui Li, Yungen Xu, Qihua Zhu
Topics & Concepts
ChemistryPoly ADP ribose polymeraseIn vitroIC50Lead compoundEnzymeStereochemistryCombinatorial chemistryDocking (animal)Cell growthMoleculeBiochemistryOrganic chemistryPolymeraseMedicineNursingPARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisToxin Mechanisms and Immunotoxins