Genomic and Resistance Epidemiology of Gram-Negative Bacteria in Africa: a Systematic Review and Phylogenomic Analyses from a One Health Perspective
John Osei Sekyere, Melese Abate Reta
Abstract
Antibiotic resistance (AR) is one of the major public health threats and challenges to effective containment and treatment of infectious bacterial diseases worldwide. Here, we used different methods to map out the geographical hot spots, sources, and evolutionary epidemiology of AR. Escherichia coli , Klebsiella pneumoniae , Salmonella enterica , Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacter spp., Neisseria meningitis/gonorrhoeae , Vibrio cholerae , Campylobacter jejuni , etc., were common pathogens shuttling AR genes in Africa. Transmission of the same clones/strains across countries and between animals, humans, plants, and the environment was observed. We recommend Enterobacter spp. or K. pneumoniae as better sentinel species for AR surveillance.