Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice
Fangzhao Wang, Shenhai Gong, Teng Wang, Lei Li, Haihua Luo, Junhao Wang, Chenyang Huang, Hongwei Zhou, Guiming Chen, Zhanguo Liu, Qifan Zhang, Yong Jiang, Peng Chen
Abstract
: Our data shows that soyasaponin II which serves as a novel inhibitor for YB-1 phosphorylation and Nlrp3 inflammasome priming could protect mice against LPS/GalN induced acute liver failure.
Topics & Concepts
InflammasomePhosphorylationPriming (agriculture)Liver failureCell biologyChemistryCancer researchImmunologyMedicineBiologyInflammationInternal medicineBotanyGerminationDiet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentInflammasome and immune disorders