Novel 4-Amino-Quinazoline moieties ligated Platinum(IV) prodrugs overcome cisplatin resistance in EGFRWT human lung cancer
Rui Li, Weiheng Zhao, Jin Chen, Huihua Xiong
Topics & Concepts
CisplatinChemistryOxaliplatinCytotoxicityProdrugQuinazolineApoptosisPharmacologyPI3K/AKT/mTOR pathwayCancer cellCancer researchA549 cellReactive oxygen speciesCancerBiochemistryIn vitroChemotherapyStereochemistryMedicineColorectal cancerInternal medicineQuinazolinone synthesis and applicationsMetal complexes synthesis and propertiesSynthesis and Biological Evaluation