One-step synthesis of cyanated pyrazolo[1,5-<i>a</i>]pyridines utilizing <i>N</i>-aminopyridines as a 1,3-dipole and a nitrogen source
Xiaotian Shi, Lin Yu, Jiaohang Wei, Limin Zhao, Pengfeng Guo, Hua Cao, Xiang Liu
Abstract
By utilizing the dual reactivity function of N -aminopyridinium ylides, we developed a direct [3 + 2]-cycloaddition of N -aminopyridinium ylides and ynals to build the pyrazolo[1,5- a ]pyridine core while introducing a cyano group.
Topics & Concepts
ChemistryAminopyridinesPyridineCycloadditionMedicinal chemistryNitrogenDipoleReactivity (psychology)Combinatorial chemistryOrganic chemistryCatalysisPathologyMedicineAlternative medicineSynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods