Identification of a novel PAK1/HDAC6 dual inhibitor ZMF-23 that triggers tubulin-stathmin regulated cell death in triple negative breast cancer
Jin Zhang, Xiya Chen, Gang Chen, Yi Li, Lin Jia, Hao Yue, Dahong Yao
Topics & Concepts
HDAC6Cancer researchTriple-negative breast cancerStathminNecroptosisBiologyAcetylationPAK1Breast cancerChemistryMicrotubuleApoptosisCancerCell biologyProgrammed cell deathKinaseBiochemistryHistoneHistone deacetylaseGeneticsGeneHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis