Electronic cigarette exposure causes vascular endothelial dysfunction due to NADPH oxidase activation and eNOS uncoupling
Mohamed A. El‐Mahdy, Mohamed G. Ewees, Mahmoud S. Eid, Elsayed M. Mahgoup, Sahar A. Khaleel, Jay L. Zweíer
Abstract
Underlying mechanisms of e-cig-induced vascular endothelial dysfunction are delineated. e-cig exposure activates and increases expression of NADPH oxidase and disrupts activation and coupling of eNOS, leading to a vicious cycle of superoxide generation and peroxynitrite formation, with tetrahydrobiopterin depletion, causing loss of NO that triggers vascular endothelial dysfunction. This process is progressive, increasing with the duration of e-cig exposure, and is more severe in the presence of nicotine, but observed even with nicotine-free vaping.
Topics & Concepts
EnosNADPH oxidaseEndothelial dysfunctionInternal medicineMedicineCardiologyChemistryEndocrinologyNitric oxideOxidative stressNitric oxide synthaseNitric Oxide and Endothelin EffectsRedox biology and oxidative stressHeart Rate Variability and Autonomic Control