Synthesis of 2-substituted bicyclo[1.1.0]butanes <i>via</i> zincocyclopropanation using bromoform as the carbenoid precursor
Léa Thai‐Savard, André B. Charette
Abstract
Through a revisited Simmons-Smith type zincocyclopropanation using bromoform as the carbenoid source, the synthesis of 2-, 2,2- and 2,4-substituted bicyclo[1.1.0]butanes is reported. Few antecedents of the derivatives have yet been described. Ultimately, the underexplored scaffolds exhibited a complete discrepency of reactivity.
Topics & Concepts
CarbenoidBromoformBicyclic moleculeChemistryMedicinal chemistryOrganic chemistryCatalysisRhodiumChloroformCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions