Selective Golgi α-mannosidase II inhibitors: <i>N</i>-alkyl substituted pyrrolidines with a basic functional group
Tomáš Klunda, Michal Hricovíni, Sergej Šesták, Juraj Kóňa, Monika Poláková
Abstract
Enzymatic assays, molecular modeling and NMR studies of novel 1,4-dideoxy-1,4-imino-<sc>l</sc>-lyxitols provided new information on the GH38 family enzyme inhibitors and their selectivity.
Topics & Concepts
ChemistryMannosidaseAlkylGroup (periodic table)Golgi apparatusStereochemistryFunctional groupBiochemistryOrganic chemistryEnzymeEndoplasmic reticulumPolymerCalcium signaling and nucleotide metabolismCarbohydrate Chemistry and SynthesisCellular transport and secretion