Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4
Chao Sun, Cuicui Shi, Xiaoyan Duan, Yi Zhang, Baocan Wang
Abstract
, a mouse model of HF was established. The results of the present study suggested that a close associated existed between DEMs and HF. Based on the results of the bioinformatics analysis, miR-618 was one of the main downregulated miRs involved in cirrhosis. In addition, miR-618 could be transferred from MSCs to LX-2 cells via exosomes; exosomal miR-618 derived from MSCs inhibited the viability and migration of LX-2 cells that were treated with TGF-β. Furthermore, exosomal miR-618 derived from MSCs attenuated the progression of HF via targeting Smad4. These findings indicated that treatment of exosomal miR-618 derived from MSCs might serve as a new strategy for HF.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesmicroRNAExosomeCancer researchFibrosisKEGGCirrhosisBiologyHepatic fibrosisEpithelial–mesenchymal transitionPathogenesisCell biologyMedicineGene expressionImmunologyGenePathologyDownregulation and upregulationGeneticsInternal medicineTranscriptomeExtracellular vesicles in diseaseLiver Disease and TransplantationMicroRNA in disease regulation