Pirfenidone: A Promising Drug in Ocular Therapeutics
Amol Chhatrapati Bisen, Sristi Agrawal, Ramakrishna Rayiti, Sachin Nashik Sanap, Arpon Biswas, Anjali Mishra, Neeraj Mohan Gupta, Rabi Sankar Bhatta
Abstract
Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and shown promise in eye care. This detailed review tracks its evolution from lung treatment to aiding eye healing as evidenced by published literature. Pirfenidone's multifaceted attributes extend to mitigating corneal fibrosis, inflammation, and trauma. Through rigorous investigations, its efficacy emerges in diabetic retinopathy, macular degeneration, and postoperative glaucoma interventions. As an unheralded protagonist, pirfenidone reshapes ocular care paradigms, inviting renewed research opportunities.