A Silyl Sulfinylamine Reagent Enables the Modular Synthesis of Sulfonimidamides via Primary Sulfinamides
Mingyan Ding, Ze‐Xin Zhang, Thomas Q. Davies, Michael C. Willis
Abstract
-silyl sulfinylamine reagent allows the rapid preparation of a broad range of (hetero)aryl, alkenyl, and alkyl primary sulfinamides, using Grignard, organolithium, or organozinc reagents to introduce the carbon fragment. Treatment of these primary sulfinamides with an amine in the presence of a hypervalent iodine reagent leads directly to NH-sulfonimidamides. This two-step sequence is straightforward to perform and provides a modular approach to sulfonimidamides, allowing ready variation of both reaction components, including primary and secondary amines.
Topics & Concepts
Hypervalent moleculeReagentChemistryPrimary (astronomy)SilylationAlkylArylCombinatorial chemistryAmine gas treatingModular designOrganic chemistryCatalysisComputer sciencePhysicsAstronomyOperating systemSynthesis and Catalytic ReactionsAdvanced Synthetic Organic ChemistrySulfur-Based Synthesis Techniques