Investigations on the Novel Antimalarial Ferroquine in Biomimetic Solutions Using Deep UV Resonance Raman Spectroscopy and Density Functional Theory
Robert Domes, Torsten Frosch
Abstract
= 257 nm, a minimal FQ concentration of 3.1 μM was detected, whereas the pre-resonant excitation wavelength 244 nm provides an LoD of 6.9 μM. These values were all up to one order of magnitude lower than the concentration found for the food vacuole of a parasitized erythrocyte.
Topics & Concepts
ChemistryRaman spectroscopyResonance (particle physics)Resonance Raman spectroscopyMembraneAnalytical Chemistry (journal)ExcitationWavelengthUltravioletProtonationDensity functional theoryBiophysicsChromatographyBiochemistryComputational chemistryOptoelectronicsAtomic physicsOpticsPhysicsElectrical engineeringEngineeringOrganic chemistryIonBiologyAdvanced biosensing and bioanalysis techniquesMalaria Research and ControlMass Spectrometry Techniques and Applications