Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity
Ruyang Yu, Jia Zhong, Qilyu Zhou, Wei Ren, Zhongjie Liu, Yifei Bian
Topics & Concepts
AngiogenesisProtein kinase BKaempferolp38 mitogen-activated protein kinasesTumor necrosis factor alphaPI3K/AKT/mTOR pathwayChemistryVascular endothelial growth factorProinflammatory cytokineCancer researchVascular permeabilityPharmacologySignal transductionInflammationCell biologyMAPK/ERK pathwayBiologyImmunologyEndocrinologyFlavonoidBiochemistryVEGF receptorsAntioxidantBarrier Structure and Function StudiesNeurological Disease Mechanisms and TreatmentsAngiogenesis and VEGF in Cancer