Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium
Rebekah E. Mahoney, Elizabeth Ochoa Thomas, Paulino Ramirez, Henry E. Miller, Adrian Beckmann, Gabrielle Zuniga, Radek Dobrowolski, Bess Frost
Abstract
depletion as a mechanism contributing to tau-induced neurotoxicity, adding an important dimension to the calcium hypothesis of Alzheimer's disease.
Topics & Concepts
CREBTauopathyCell biologyBiologyNuclear export signalInduced pluripotent stem cellNeuroscienceNeurotoxicityNeurodegenerationNucleusCell nucleusChemistryGeneticsGeneTranscription factorDiseaseInternal medicineMedicineToxicityEmbryonic stem cellOrganic chemistryAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesNeuroscience and Neuropharmacology Research