Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by <i>Zataria multiflora</i> extract and carvacrol.
Fatemeh Amin, Ali Roohbakhsh, Arghavan Memarzia, Hamid Reza Kazerani, Mohammad Hossein Boskabady
Abstract
OBJECTIVE: hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stress induced by inhaled PQ were examined in this study. MATERIALS AND METHODS: (200 and 800 mg/kg/day) or carvacrol (20 and 80 mg/kg/day) for 16 days after the end of exposure to PQ. Exposure to PQ was performed 8 times, every other day, each time for 30 min. After the end of the treatment period, different variables were measured. RESULTS: , and IL-6 but increased IFN-γ and IFN-γ/IL-6 ratio compared to un-treated PQ exposed group (p<0.05 to p<0.001). CONCLUSION: and carvacrol improved systemic inflammation oxidative biomarkers induced by inhaled PQ which may indicate therapeutic potential of the plant and its constituent, carvacrol in systemic inflammation and oxidative biomarkers induced by inhaled PQ.