Towards a post-pandemic future for global pathogen genome sequencing
Jason T. Ladner, Jason W. Sahl
Abstract
Pathogen genome sequencing has become a routine part of our response to active outbreaks of infectious disease and should be an important part of our preparations for future epidemics. In this Essay, we discuss the innovations that have enabled routine pathogen genome sequencing, as well as how genome sequences can be used to understand and control the spread of infectious disease. We also explore the impact of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic on the field of pathogen genomics and outline the challenges we must address to further improve the utility of pathogen genome sequencing in the future.
Topics & Concepts
BiologyGenomePandemicOutbreakGenomicsPathogenDNA sequencingInfectious disease (medical specialty)Whole genome sequencingComputational biologyCoronavirus disease 2019 (COVID-19)GeneticsVirologyDiseaseGeneMedicinePathologyBacteriophages and microbial interactionsViral gastroenteritis research and epidemiologySARS-CoV-2 and COVID-19 Research