Neurotrophin signalling in the human nervous system
Sarah Ateaque, Spyros Merkouris, Yves‐Alain Barde
Abstract
This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed.
Topics & Concepts
Trk receptorNeurotrophinTropomyosin receptor kinase BTropomyosin receptor kinase CNeuroscienceLow-affinity nerve growth factor receptorTropomyosin receptor kinase ANervous systemReceptor tyrosine kinaseReceptorBiologySignallingNeurotrophic factorsCell biologyPlatelet-derived growth factor receptorBiochemistryGrowth factorNerve injury and regenerationSignaling Pathways in DiseaseNeurogenesis and neuroplasticity mechanisms