Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches
Patrick Pfaff, Felix Anderl, Moritz Fink, Moritz Balkenhohl, Erick M. Carreira
Abstract
-half-lives. Using the method, we introduce for the first time the design and synthesis of a diacetylene platform. It permits implementation of consecutive and diversity-oriented approaches linking two different conjugants to independently addressable acetylenes within a common photoswitchable azotriazole. This is showcased in the synthesis of several photoswitchable conjugates, with potential applications as photoPROTACs and biotin conjugates.
Topics & Concepts
ChemistryDiacetylenePhotoisomerizationConjugatePhotoswitchCombinatorial chemistrySonogashira couplingClick chemistryNanotechnologyPhotochemistryOrganic chemistryCatalysisIsomerizationMathematicsPolymerPalladiumMaterials scienceMathematical analysisPolymerizationPhotochromic and Fluorescence ChemistryClick Chemistry and ApplicationsPorphyrin and Phthalocyanine Chemistry