Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions
Zhangming Chen, Jie Hu, Yuanmin Xu, Wei He, Lei Meng, Ting Huang, Songcheng Ying, Zhe Jiang, Aman Xu
Abstract
BACKGROUND: , especially CagA+ strain-induced gastric mucosal lesions, on the development of GC is unknown. AIM: strains causes pathological changes in the gastric mucosa of mice. METHODS: strains (CagA+ or CagA-) and CTS (or PBS) intragastrically, and establishment of the chronic infection model was verified using polymerase chain reaction and sequencing of isolated strains. Hematoxylin and eosin staining was used to assess mucosal erosion in the stomach and toxicity to the liver and kidney. RESULTS: strain group. CONCLUSION: by decreasing the protein expression of SHP2.
Topics & Concepts
MedicineCancerGeneCancer researchInternal medicineGeneticsBiologyNatural product bioactivities and synthesisMycobacterium research and diagnosisPhytochemical Studies and Bioactivities