Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro
D. Vu, Alessio Bonucci, Manon Brenière, Metztli Cisneros‐Aguirre, Philippe Pelupessy, Ziqing Wang, Ludovic Carlier, Guillaume Bouvignies, Patricia Cortés, Aneel K. Aggarwal, Martin Blackledge, Zoher Gueroui, Valérie Belle, Jeremy M. Stark, Mauro Modesti, Fabien Ferrage
Topics & Concepts
Ku80Ku70DNA repair protein XRCC4Non-homologous end joiningDNA repairDNA ligaseCell biologyDNA damageScaffold proteinBiologyDNAChemistryGeneticsDNA-binding proteinSignal transductionGeneNucleotide excision repairTranscription factorDNA Repair MechanismsRNA Research and SplicingRNA modifications and cancer