Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, <i>in silico</i> studies, and antiproliferative evaluation
Mohammed S. Taghour, Hazem A. Mahdy, Maher H. Gomaa, Ahmed Aglan, Mahmoud Gomaa Eldeib, Alaa Elwan, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Mohamed M. Khalifa, Ibrahim H. Eissa, Hazem Elkady
Abstract
exhibited interactions with the key amino acids in a similar way to sorafenib.
Topics & Concepts
BenzoxazoleApoptosisSorafenibIC50ChemistryCell cultureCell growthStereochemistryIn silicoDocking (animal)Inhibitory postsynaptic potentialBiological activityStructure–activity relationshipLead compoundIn vitroBiochemistryBiologyCancer researchEndocrinologyMedicineGeneOrganic chemistryHepatocellular carcinomaGeneticsNursingAngiogenesis and VEGF in CancerPI3K/AKT/mTOR signaling in cancerBioactive Compounds and Antitumor Agents