Statistical shape modeling reveals the link between right ventricular shape, hemodynamic force, and myocardial function in patients with repaired tetralogy of Fallot
Sarah Kollar, Elias Balaras, Laura Olivieri, Yue‐Hin Loke, Francesco Capuano
Abstract
We combine statistical shape modeling with physics-based analysis of 4D flow data to elucidate the interplay between RV shape, hemodynamic forces, and clinical dysfunction in repaired tetralogy of Fallot. We are the first to show that ventricular remodeling is related to hemodynamic force magnitude and direction, global and regional functional parameters, and exercise intolerance. Identification of patients based on the shape variations described in this study could help identify those at risk for irreversible dysfunction.
Topics & Concepts
Tetralogy of FallotHemodynamicsCardiologyInternal medicineVentricular functionMedicineHeart diseaseCongenital Heart Disease StudiesCardiovascular Function and Risk FactorsCardiac Structural Anomalies and Repair