Proteome Integral Solubility Alteration (PISA) Assay in Mammalian Cells for Deep, High-Confidence, and High-Throughput Target Deconvolution
Xuepei Zhang, Olga Lytovchenko, Susanna L. Lundström, Roman A. Zubarev, Massimiliano Gaetani
Abstract
J Biol Chem (2021), DOI: 10.1016/j.jbc.2021.10153 Graphical abstract.
Topics & Concepts
ProteomeProteomicsDeconvolutionChemistryComputational biologyDrug discoveryChromatographyComputer scienceBiologyBiochemistryAlgorithmGeneAdvanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and ApplicationsProtein purification and stability