Dysregulation of lncRNA in <i>Helicobacter pylori</i>‐Infected Gastric Cancer Cells
Leila Yousefi, Hamid Owaysee Osquee, Reza Ghotaslou, Mohammad Ahangarzadeh Rezaee, Tahereh Pirzadeh, Javid Sadeghi, Fatemeh Hemmati, Bahman Yousefi, Seyyed Yaghoub Moaddab, Mehdi Yousefi, Maryam Shirmohammadi, Mohammad Hossein Somi, Khudaverdi Ganbarov, Hossein Samadi Kafil
Abstract
Helicobacter pylori ( H. pylori ) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein‐coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.