Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus
Marat Khodoun, Ameet A. Chimote, Farhan Z. Ilyas, Heather J. Duncan, Halima Moncrieffe, K. Shashi Kant, Laura Conforti
Abstract
T cell renal infiltration, and reduced survival versus healthy donor PBMC engrafted mice. Kv1.3-NP treatment of patient PBMCs before engraftment decreased CD40L/IFNγ and prolonged survival of LN mice. These data show the potential benefits of targeting Kv1.3 in LN.
Topics & Concepts
Lupus nephritisGene knockdownIn vivoImmunologyIn vitroSystemic lupus erythematosusDiseaseLupus erythematosusMedicineBiologyCell culturePathologyGeneticsAntibodySystemic Lupus Erythematosus ResearchT-cell and B-cell ImmunologyGalectins and Cancer Biology