Litcius/Paper detail

Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles

Hillary P. Handler, Lisa Duvick, Jason S. Mitchell, Marija Cvetanović, Molly Reighard, Alyssa Soles, Kathleen B. Mather, Orion Rainwater, Shannah Serres, Tessa Nichols‐Meade, Stephanie L. Coffin, Yun You, Brian L. Ruis, Brennon O’Callaghan, Christine Henzler, Huda Y. Zoghbi, Harry T. Orr

2022Neuron29 citationsDOIOpen Access PDF

Topics & Concepts

Spinocerebellar ataxiaBiologyPhenotypeNeurodegenerationNuclear localization sequenceMutantTranscriptomeTrinucleotide repeat expansionNuclear proteinNeuroscienceCell biologyGeneGeneticsDiseaseGene expressionPathologyTranscription factorMedicineAlleleGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyRNA Research and Splicing