Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles
Hillary P. Handler, Lisa Duvick, Jason S. Mitchell, Marija Cvetanović, Molly Reighard, Alyssa Soles, Kathleen B. Mather, Orion Rainwater, Shannah Serres, Tessa Nichols‐Meade, Stephanie L. Coffin, Yun You, Brian L. Ruis, Brennon O’Callaghan, Christine Henzler, Huda Y. Zoghbi, Harry T. Orr
Topics & Concepts
Spinocerebellar ataxiaBiologyPhenotypeNeurodegenerationNuclear localization sequenceMutantTranscriptomeTrinucleotide repeat expansionNuclear proteinNeuroscienceCell biologyGeneGeneticsDiseaseGene expressionPathologyTranscription factorMedicineAlleleGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyRNA Research and Splicing