Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková‐Kaiserová, Evžen Bouřa, Jan Weber, Radim Nencka
Abstract
pharmacokinetic properties and exhibited moderate antiviral activity in cell-based assays. These findings provide a robust foundation for developing targeted nsp14 inhibitors as a potential treatment for COVID-19 and related diseases.
Topics & Concepts
AdenosineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MethyltransferaseCoronavirus disease 2019 (COVID-19)ChemistryPharmacologyBiologyBiochemistryMedicineInternal medicineGeneInfectious disease (medical specialty)MethylationDiseaseBiochemical and Molecular ResearchPeptidase Inhibition and AnalysisTuberculosis Research and Epidemiology