Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood–brain barrier permeability for drug delivery to the brain in a non-human primate
Keisuke Tachibana, Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Ryuichi Hirayama, Yumi Iwashita, Itsuki Nishino, Yukio Ago, Hiroyuki Takeda, Hiroki Kuniyasu, Masuo Kondoh
Topics & Concepts
Monoclonal antibodyBlood–brain barrierPermeability (electromagnetism)PrimateDrugDrug deliveryPharmacologyClaudinDrug delivery to the brainChemistryAntibodyMedicineImmunologyTight junctionBiologyNeuroscienceMembraneCentral nervous systemInternal medicineBiochemistryOrganic chemistryBarrier Structure and Function StudiesNeurological Disease Mechanisms and TreatmentsConnexins and lens biology