Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice
Yun Li, Rodney M. Ritzel, Niaz Khan, Tuoxin Cao, Junyun He, Zhuofan Lei, Jessica J. Matyas, Boris Sabirzhanov, Simon Liu, Hui Li, Bogdan A. Stoica, David J. Loane, Alan I. Faden, Junfang Wu
Abstract
These findings indicate that pharmacological microglia-deletion reduces neuroinflammation in the injured spinal cord and brain, improving recovery of cognition, depressive-like behavior, and motor function.
Topics & Concepts
NeuroinflammationMicrogliaSpinal cord injuryMedicineSpinal cordNeurodegenerationNeuroprotectionNeurosciencePathologyInflammationAnesthesiaInternal medicinePsychologyDiseasePsychiatryNeuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury ResearchNeonatal and fetal brain pathology