Pivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity for <sup>19</sup>F-MR imaging
Lodovico Gatti, Cristina Chirizzi, Giulia Rotta, Pietro Milesi, María Sancho‐Albero, Victor Sebastián, Anna Mondino, Jesús Santamaría, Pierangelo Metrangolo, Linda Chaabane, Francesca Baldelli Bombelli
Abstract
The formation of a protein corona (PC) strongly influences the cellular internalization mechanisms of fluorinated NPs. In particular, the PC facilitates the NP cellular uptake in microglia cells enhancing 19 F-MRI sensitivity.
Topics & Concepts
InternalizationChemistryIn vivoTranslation (biology)CellSurface modificationNanoparticleBiophysicsNanotechnologyMagnetic resonance imagingBiomedical engineeringNuclear magnetic resonanceMaterials scienceBiochemistryMessenger RNAMedicineBiologyPhysicsRadiologyBiotechnologyGenePhysical chemistryLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and ApplicationsNanoparticle-Based Drug Delivery