Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation
Laura Francis, J. Brian Houston, David Hallifax
Topics & Concepts
In vivoIn vitroChemistryClearanceFree fractionPlasma protein bindingPharmacologyBiochemistryBiologyMedicineBiotechnologyUrologyDrug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismPharmacological Effects and Toxicity Studies