Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of Concern
Tai Young Kim, Sangeun Jeon, Meehyun Ko, Young Eun Du, So-Ri Son, Dae Sik Jang, Seungtaek Kim, C. Justin Lee
Abstract
Several plant-derived natural products with anti-SARS-CoV-2 activity have been evaluated for the potential to serve as chemotherapeutic agents for the treatment of COVID-19. Codonopsis lanceolata (CL) has long been used as a medicinal herb in East Asian countries to treat inflammatory diseases of the respiratory system but its antiviral activity has not been investigated so far. Here, we showed that CL extract and its active compound lancemaside A (LA) displayed potent inhibitory activity against SARS-CoV-2 infection using a pseudotyped SARS-CoV-2 entry assay system.
Topics & Concepts
Vero cellMechanism of actionBiologyIC50SyncytiumLipid bilayer fusionCell fusionVirologyViral entryPharmacologyIn vitroVirusChemistryCellBiochemistryViral replicationComputational Drug Discovery MethodsEssential Oils and Antimicrobial ActivitySARS-CoV-2 and COVID-19 Research